Nicotinamide phosphoribosyltransferase (Nampt) in Lateral Hypothalamus Maintains Skeletal Muscle Functions Through Lactate-Mediated Calcium Signalling in Male Mice.

ABSTRACT:

Background

Sarcopenia has become an urgent socioeconomic problem in rapidly aging societies. The pathogenesis of age-associated sarcopenia is not fully understood and no effective therapeutic strategies have been developed to date. Recent studies have suggested the importance of the functional linkage between the brain and skeletal muscles in the pathogenesis of sarcopenia. However, the functional connections between the brain and skeletal muscles, particularly between the hypothalamus and skeletal muscles, remain unclear. In this study, we focused on the importance of nicotinamide adenine dinucleotide (NAD⁺) metabolism in the lateral hypothalamus (LH) and explored the importance of the NAD⁺-mediated functional connection between the LH and skeletal muscle and

SUBMITTER: Eguchi T 

PROVIDER: S-EPMC12439195 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature