Integration of Bioinformatics, Serum Pharmacochemistry, and Metabolomics to Reveal the Mechanisms of Danggui Buxue Decoction in Anti-Rheumatoid Arthritis Through Inflammation and NF-κB Signaling Pathway Regulation.

ABSTRACT:

Objective

Rheumatoid arthritis (RA) remains a significant clinical challenge due to the limited efficacy and adverse effects associated with conventional treatments. Danggui buxue decoction (DBD), renowned for its qi-tonifying, blood-nourishing, and anti-inflammatory properties, has shown promising potential in the management of RA. This study investigates the mechanisms of DBD in RA through bioinformatics and experimental analyses, providing a scientific foundation for its clinical application and further development.

Methods

The chemical components and blood-absorbed components of DBD were identified using UPLC-MS/MS. Bioinformatics approaches were applied to identify differentially expressed genes (DEGs) between RA patients and healthy individuals, and to predict potentia

SUBMITTER: Du L 

PROVIDER: S-EPMC12439196 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature