Eliminating the high-risk CTV1 margin in DAHANCA oropharyngeal radiotherapy: Dosimetric impact on dysphagia and organ-at-risk doses.

ABSTRACT:

Background and purpose

Radiotherapy for head and neck cancer must balance tumour control with late toxicities such as dysphagia and xerostomia. Recent retrospective studies suggest that the margin from the gross tumour volume (GTV) to the high-dose clinical target volume (CTV1) may not be critical for local control, while larger irradiated volumes increase the risk of toxicity. The study quantifies potential reductions in dose to organs at risk (OARs) and predicted dysphagia risk when the standard 5 mm GTV-to-CTV1 margin is eliminated in oropharyngeal cancer. Patient/material and methods: Retrospectively 30 oropharyngeal cancer patients treated consecutively during 2023 according to the DAHANCA guidelines (5 mm GTV-to-CTV1 margin) were selected. For each patient, a standard plan an

SUBMITTER: Hansen CR 

PROVIDER: S-EPMC12439217 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature