Targeting CB1R Rewires Ca²⁺-Dependent Mitophagy to Promote Nerve Regeneration.

ABSTRACT: Background: Ion homeostasis is disrupted following nerve injury, and elevated Ca²⁺ levels have been reported to induce Schwann cell (SC) death. Notably, clinical interventions such as electrical stimulation enhance Ca²⁺ influx and facilitate nerve regeneration. These findings highlight the need to clarify the precise role of Ca²⁺ signaling in nerve regeneration. Methods: We assessed extracellular Ca²⁺ concentrations in both human and murine peripheral nerve tissues after injury. Transcriptomic profiling identified CB1R as a key Ca²⁺-related gene and in vitro validation was performed with primary cultured SC and nerve explants. A sciatic nerve crush model was established in SC-specific CB1R knockout mice. Mitophagy,

SUBMITTER: Wang N 

PROVIDER: S-EPMC12439258 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature