Regiodivergent Interrupted Ni-Catalyzed Chain-Walking of Unsaturated Alcohol Side-Chains via Traceless Activating Groups.

ABSTRACT: Herein, we describe a regiodivergent interrupted chain-walking of unsaturated aliphatic alcohols. The method leverages the potential of traceless groups to forge C(sp³)-C(sp³) and C(sp³)-nitrogen bonds at distal methylene sp³ C-H sites, with site selectivity dictated by a judicious choice of the ligand. The protocol is distinguished by its broad applicability, offering unconventional disconnections to access β/γ-substituted aliphatic alcohols that are difficult to reach otherwise.

SUBMITTER: Wang H 

PROVIDER: S-EPMC12439304 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature