Novel biomarkers for prognosis in patients with localized prostate cancer.

ABSTRACT: The outcome for patients with localized prostate cancer (LPCa) is markedly variable, with different survival rates. The objective of the present study was to investigate how the levels of blood-related soluble factors and the densities of immune T-cell subsets could impact the prognosis of LPCa. The progression-free survival of 139 patients with LPCa was retrospectively analyzed after standard treatments. Survival was revealed to be associated with the levels of circulating HER-2/neu extracellular domain (HER-ECD), transforming growth factor β (TGFβ) and interleukin-8 (IL-8), as well as with the frequencies of total and prostate-specific antigen (PSA)-peptide-specific CD8⁺ T-cell subsets. Based on these analyses, patients with LPCa could be grouped into those having lower levels

SUBMITTER: Goulielmaki M 

PROVIDER: S-EPMC12439455 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature