A strategy targeting ferroptosis for mitochondrial reprogramming and intervertebral disc degeneration therapy.

ABSTRACT: Background: Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, yet current therapies fail to reverse the degenerative process or restore disc function. Ferroptosis, a form of iron-dependent cell death characterized by lipid peroxidation, has been implicated in IVDD progression. Methods: We synthesized Deferoxamine mesylate (DFOM)-loaded cerium oxide nanoparticles (DFOM@CeO₂) as a novel ferroptosis-targeting therapeutic. Results: DFOM@CeO₂ exhibited dual functionality by scavenging reactive oxygen species (ROS) and chelating excess iron, thereby protecting nucleus pulposus (NP) cells from ferroptosis and extracellular matrix (ECM) degradation. DFOM@CeO₂ demonstrated strong antioxidant capacity, effectively reduc

SUBMITTER: Wu T 

PROVIDER: S-EPMC12439470 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature