Adherence to recombinant human growth hormone therapy in children: influencing factors and clinical implications.

ABSTRACT:

Background

Adherence to recombinant human growth hormone (rhGH) therapy is crucial for achieving optimal outcomes in children with growth disorders. However, non-adherence remains a significant challenge, affecting treatment efficacy and patient prognosis. This study evaluates adherence rates to rhGH therapy in pediatric patients, identifies key influencing factors, and explores strategies to improve adherence.

Methods

A retrospective analysis was conducted on 8,621 pediatric patients receiving rhGH therapy in China. Adherence was assessed by the proportion of prescribed doses taken, with good adherence defined as ≥86%. Factors influencing adherence were analyzed using logistic regression models, considering variables such as age, GH formulation type, treatment duration, and

SUBMITTER: Chang W 

PROVIDER: S-EPMC12439475 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature