Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm.

ABSTRACT: A global priority for ameliorating male factor infertility includes identification of environmental factors and mechanisms that impact sperm function. Detection of endocrine disrupting chemicals (EDC) in seminal plasma and within the female reproductive tract has created an urgent need to understand how environmental stressors alter postejaculatory sperm function. Tributyltin chloride (TBT) is an EDC and epigenetic modifier that causes reproductive disorders. The consequences of TBT exposure on postejaculatory sperm remain unknown. The present study was aimed at identifying structural, genomic, and epigenomic consequences of TBT exposure to postejaculatory sperm. Bovine sperm were exposed to TBT (0, 1, 10, 100 nM) for 24 h followed by quantification of sperm kinematics, DNA integrity, and

SUBMITTER: Siddique MS 

PROVIDER: S-EPMC12439583 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature