Expedited Synthesis of Axially Chiral 3-Monosilyl and 3,3'-Bis-silyl Biphenols, Binaphthols, and Phosphoramidites Enabled by Catalytic Two-Fold C-H Silylation with a Traceless Acetal Directing Group.

ABSTRACT: The design and development of supporting ligands have significantly propelled the discovery of new catalytic reactions and the improvement of existing ones. Among these, axially chiral biphenols and 1,1'-binaphthalene-2,2'-diol (BINOL) are some of the most privileged ligands used in a wide array of enantioselective reactions. Despite the well-established benefits of structural modifications to biphenol and BINOL scaffolds, particularly at their 3,3'-positions-for enhancing reactivity and stereofidelity in catalytic asymmetric transformations-only a limited number of 3,3'-bis-functionalized biphenols and BINOLs are currently available. Here, we report a unified strategy to rapidly access a range of axially chiral 3-monosilyl and 3,3' bis-silyl-substituted and biphenols and BINOLs as well as

SUBMITTER: Nguyen HH 

PROVIDER: S-EPMC12439854 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature