Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

ABSTRACT: The nucleus accumbens (NAc) is a key component of the mesolimbic dopamine system that critically regulates many behaviors related to reward and motivation. The NAc is implicated in several neuropsychiatric disorders, including major depressive disorder, schizophrenia, and substance use disorders. Rodent studies have identified spatial organization of heterogeneous medium spiny neuron (MSN) subtypes across the NAc core and shell, but the extent to which this cellular diversity and spatial organization is conserved in the human brain remains unclear. Here, we generated a spatiomolecular atlas of NAc cell types and spatial domains by integrating spatial transcriptomics and single-nucleus RNA sequencing data from postmortem NAc tissue from 10 neurotypical adult donors. We identified 20 transcr

SUBMITTER: Ravichandran P 

PROVIDER: S-EPMC12439884 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature