Plasticity in thoracic paravertebral sympathetic postganglionic neurons after high spinal cord transection.

ABSTRACT: Various pre-sympathetic descending brain circuits recruit spinal cord preganglionic neurons to encode central sympathetic drive via their synaptic actions onto sympathetic postganglionic neurons (SPNs) - the final sympathetic output neurons. Thoracic paravertebral ganglia SPNs (tSPNs) provide distributed control over body tissue systems via functional subpopulations. High thoracic spinal cord injuries (SCIs) compromise descending excitatory drive to SPNs, causing dysautonomias including hypotension. In adult mice, we tested whether the SCI-induced chronic reduction in tSPN activity leads to homeostatic increases in their excitability. tSPN excitability spanned a >10 fold range in both sham and SCI populations, governed by a strong linear (ohmic) relationship between cell resistance and thr

SUBMITTER: Li Y 

PROVIDER: S-EPMC12439890 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature