EHMT2 Controls Neural Crest-Derived Craniofacial Development but is Dispensable in Limb Development.

ABSTRACT: Post-translational modifications of histones, such as methylation of histone H3 at lysine 9 (H3K9), play critical roles in regulating chromatin structure and gene expression. EHMT2 (also called G9A), a histone methyltransferase, mediates H3K9 mono- and dimethylation and has been implicated in both transcriptional repression and context-specific gene activation. Although global knockout of the mouse Ehmt2 gene results in early embryonic lethality, tissue-specific knockouts have uncovered diverse roles in organ development. However, how EHMT2 contributes to skeletal development in a lineage-specific manner remains to be fully elucidated. Here, we investigated the role of EHMT2 in skeletal development by conditionally inactivating Ehmt2 in neural crest-derived and mesoderm-deriv

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12439983 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature