External validation and recalibration of office- and laboratory-based cardiovascular risk scores for prediction of 10-year risk of fatal cardiovascular disease in 112,262 adults in Mexico City.

ABSTRACT:

Background

Cardiovascular disease (CVD) is the leading cause of mortality in Latin America, yet most CVD risk prediction models were developed in high-income countries with limited validations in these settings.

Objectives

To externally validate CVD risk prediction models for 10-year fatal CVD, and recalibrate the Globorisk-fatal model in Mexican population.

Methods

We analyzed 112,262 adults ≥40 years from the Mexico City Prospective Study. Outcomes were restricted to fatal CVD, including myocardial infarction (MI) and stroke, censored at 10 years. CVD risk was estimated using the laboratory- and office-based Framingham, Globorisk, Globorisk-LAC, WHO, and SCORE2 equations. Discrimination was assessed with Harrell's c-statistic and AUROCs, calibration with mean estima

SUBMITTER: Perezalonso-Espinosa J 

PROVIDER: S-EPMC12440042 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature