Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with Asthma living in Urban Environments.

ABSTRACT:

Background

Childhood-onset asthma is highly heritable, with nearly 200 risk loci identified in genome-wide association studies. Aggregated polygenic risk scores can be used to quantify genetic predisposition to asthma, but their power to predict asthma severity in multi-ancestral groups has not been determined.

Objective

Our aim was to examine the predictive power of biobank-derived asthma polygenic risk scores in children with asthma living in urban environments.

Methods

We generated polygenic risk scores for asthma, derived from a large-scale genome-wide association meta-analysis, in four multi-ancestry asthma study cohorts of children living in urban environments. We assessed genetic predictions across different subphenotypes of asthma and tested for associations b

SUBMITTER: Dapas M 

PROVIDER: S-EPMC12440043 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature