Assessing long-term pleiotropic effects of potential novel triglyceride-lowering medications using variants identified by Mendelian randomization.

ABSTRACT: Drugs targeting triglyceride (TG)-associated genes have the potential to improve cardiovascular outcomes. However, we know little regarding the potential additional benefits or deleterious effects of such targeting. As such, in ancestry-specific cohorts of European ancestry (EA) and African ancestry (AA) at Vanderbilt (BioVU), we used PheWAS to test associations between measured TG levels and validated variants previously associated with TG levels in Mendelian randomization studies. We replicated results in All of Us (AoU). In the BioVU EA cohort (n=63,094), 9 of 10 validated SNPs had significant or suggestive associations with lipid and cardiovascular phenotypes, largely consistent with AoU participants of EA (n=97,545). In the BioVU AA cohort (n=12,515) and AoU AA cohort (n=31,710), resu

SUBMITTER: Outland E 

PROVIDER: S-EPMC12440046 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature