GWAS for Periodontitis Phenotypes Using Multi-Ancestry All of Us Research Platform.

ABSTRACT: Periodontitis is a multifactorial inflammatory disease whose pathogenesis is associated with intricate interactions between genetic and environmental factors. Leveraging electronic health records data from the All of Us Research Program, we stratified periodontitis by clinically relevant dimensions: stage, grade, and extent. Based on these phenotypes, we performed a multi-ancestry genome-wide association study, focusing on predominant ancestry populations of African, European, and Admixed American. Our study cohort comprised 3,881 periodontitis patients and a control group of 10,760 patients with dental caries and without periodontitis. Ancestry-specific GWAS revealed significant genetic associations (P<5×10^-8) in periodontitis grade phenotypes at the LINC00294 and CLMN loci in

SUBMITTER: Sanders K 

PROVIDER: S-EPMC12440056 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature