Multiple Psychiatric Traits Enriched for Brain Tissues in the Early Postpartum Period.

ABSTRACT:

Background

The perinatal period is a high-risk time for onset of various psychiatric disorders. However, it is unclear how genetic risk factors for these disorders interact with biological changes associated with pregnancy and postpartum. This study evaluates whether psychiatric genome-wide association study (GWAS) results are enriched within various brain regions across the perinatal period.

Methods

Tissue-specific enrichment analyses were conducted to estimate the potential impact of GWAS loci on transcriptional changes in the brain across the perinatal period. GWAS summary statistics were obtained for 26 psychiatric phenotypes. RNA-sequencing data was acquired from four brain regions (hypothalamus, hippocampus, cerebellum, and neocortex) in mice at six timepoints (virgin,

SUBMITTER: Berthold N 

PROVIDER: S-EPMC12440057 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature