Incidentally discovered Covert Cerebrovascular Disease by CT versus MRI: Agreement and Prognostic Value for Stroke and Dementia in a Large Real-World Cohort.

ABSTRACT:

Background

Covert cerebrovascular disease (CCD), comprising covert brain infarction (CBI) and white matter disease (WMD), is common in older adults and linked to increased risk of stroke and dementia. While most CCD research relies on MRI, CT remains the predominant imaging modality in clinical care. The influence of imaging modality on detection and prognosis of incidentally discovered CCD remains unclear.

Methods

We identified 18,626 patients aged ≥50 years from Kaiser Permanente Southern California who underwent both CT and MRI brain scans within 30 days between 2009-2022. Patients with known prior stroke or dementia were excluded. Natural language processing algorithms were applied to radiology reports to identify CBI and WMD status and WMD severity (none, mild, moderate

SUBMITTER: Kent DM 

PROVIDER: S-EPMC12440058 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature