Processing bodies promote lysosomal quality control and cell survival during recovery from lysosomal damage.

ABSTRACT: Lysosomes are essential for cell survival but are highly susceptible to diverse physical and pathological stressors. Thus, the ability to initiate an acute damage response and promote recovery after stressor resolution is critical for maintaining cellular homeostasis and viability. Although recent studies have advanced our understanding of acute responses to lysosomal injury, the molecular mechanisms governing the recovery stage and distinguishing it from the acute phase remain poorly defined. Here, we delineate a key difference between these two stages in translational regulation and uncover lysosomal recovery from acute damage as a novel trigger for processing body (PB) formation. PBs are membraneless biomolecular condensates involved in RNA metabolism and translational reprogramming. We

SUBMITTER: Jia J 

PROVIDER: S-EPMC12440071 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature