Establishing a new rat model to investigate pathophysiology and bone healing in posttraumatic lymphedema.

ABSTRACT:

Introduction

Posttraumatic lymphedema is a common complication after open and closed fractures with soft tissue trauma. Even though there is quite certain consensus about the basic mechanisms of lymphedema formation, the pathophysiology on a cellular and molecular base is largely unknown. Furthermore, there is currently no data on the interaction of lymphedema and bone regeneration. Subsequently, the aim of this study was to establish an animal model specific to posttraumatic lymphedema, which can be used to conduct future investigations into the pathophysiology and bone regeneration in lymphedema.

Methods

The test animals (rats)In wild-type Fisher 344 rats were divided into three groups: group one had an isolated bone defect, group two had an isolated soft tissue defect, an

SUBMITTER: Reinkemeier F 

PROVIDER: S-EPMC12440177 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature