The Salmonella phage shock protein system is required for defense against host antimicrobial peptides.

ABSTRACT: Macrophages are professional phagocytes that play a major role in engulfing and eliminating invading pathogens. Some intracellular pathogens, such as Salmonella enterica serovar Typhimurium, exploit macrophages as niches for their replication, which requires precise and dynamic modulation of bacterial gene expression in order to resist the hostile intracellular environment. Here, we present a comprehensive analysis of the global transcriptome of S. Typhimurium across four stages of infection of primary macrophages. Our results revealed a profound change in early-stage gene expression dominated by pathways linked to metabolic processes required for Salmonella adaptation to the proinflammatory conditions of the macrophage. We identified the phage shock protein (Psp) system to be highly expre

SUBMITTER: Massicotte MA 

PROVIDER: S-EPMC12440182 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature