Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage assisted behavioral innovation and testing system.

ABSTRACT: Mice are among the most prevalent animal models used in neuroscience, benefiting from the extensive physiological, imaging, and genetic tools available to study their brain. However, the development of novel and optimized behavioral paradigms for mice has been laborious and inconsistent, impeding the investigation of complex cognitions. Here, we present a home-cage assisted mouse behavioral innovation and testing system (HABITS), enabling free-moving mice to learn challenging cognitive behaviors in their home-cage without any human involvement. Supported by the general programming framework, we have not only replicated established paradigms in current neuroscience research but also developed novel paradigms previously unexplored in mice, resulting in more than 300 mice demonstrated in vari

SUBMITTER: Yu B 

PROVIDER: S-EPMC12440354 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature