Considerations on Structural Vaccinology and Epitope Screening of Calcium-Dependent Protein Kinases 8 as a Potential Vaccine Target Against <i>Toxoplasma gondii</i>.

ABSTRACT: Introduction: Toxoplasma gondii (T. gondii) is a widely prevalent parasite from the phylum apicomplexan and is the causative agent of toxoplasmosis, which affects almost all warm-blooded animals, including humans. Presently, conventional treatments for toxoplasmosis have limited effectiveness against the cystic forms of the parasite. Thus, developing an efficient and safe vaccine for control and prevention of toxoplasmosis is crucial. Calcium-dependent protein kinases (CDPKs) are essential in governing crucial biological processes like anchoring to host cell, cellular infiltration, dynamic locomotion, and escape mechanisms. Because there are no reports on immunization with CDPK8 to date, this study evaluated the fundamental biochemical traits and immunogenic epitopes o

SUBMITTER: Abedi A 

PROVIDER: S-EPMC12440659 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature