The Interaction Among Depressive Symptoms, Pain, and Frailty in Middle-Aged and Older Adults: A Longitudinal Cross-Lagged Panel Analysis.

ABSTRACT: Background: Depressive symptoms, pain, and frailty interactions in middle-aged and older adults do have longitudinal research support, yet the currently available evidence remains insufficient for a comprehensive understanding. This study aimed to examine their interrelationships and underlying mechanisms. Methods: This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), which includes four assessments for depressive symptoms, pain, and frailty over 7 years. We included 4961 participants aged 45 years and older in our analysis. We employed cross-lagged panel models (CLPMs) and random intercept CLPMs (RI-CLPMs) to analyze the bidirectional temporal relationships at the between-person and within-person levels. Results: Cross-lagged panel

SUBMITTER: Song TM 

PROVIDER: S-EPMC12440664 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature