Synergistic role of blood-labyrinth barrier permeability and endolymphatic hydrops: a comparative perspective in Meniere's disease and vestibular migraine.

ABSTRACT:

Objective

This study compares the delayed gadolinium-enhanced MRI characteristics of Ménière's disease (MD) and vestibular migraine (VM) to develop a multiparametric model that incorporates endolymphatic hydrops (EH), blood-labyrinth barrier permeability, and their asymmetry. Additionally, it investigates the correlations between these imaging features and hearing loss across various frequencies.

Methods

A total of 79 patients-47 with MD and 32 with VM-were enrolled in the study between June 2023 and April 2025. All participants underwent a comprehensive medical history assessment, neurotologic evaluation, audiological testing, and a 3D SPACE FLAIR MRI conducted 4 h after the administration of intravenous gadolinium contrast agents. EH, the signal intensity ratio (SIR) of th

SUBMITTER: Yin H 

PROVIDER: S-EPMC12440718 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature