Association between onset age and mortality gradients in advanced cardiovascular-kidney-metabolic syndrome.

ABSTRACT:

Introduction

Advanced cardiovascular-kidney-metabolic (A-CKM) syndrome portends severe prognosis, but how onset age affects mortality risk remains unquantified.

Methods

This study analyzed 179,328 participants from the Kailuan cohort in Tangshan, China (2006-2022). Using weighted Cox models and stratified analyses, we assessed the association of age at onset with all-cause mortality risk.

Results

Among 17,283 incident A-CKM cases matched to age-stratified controls, early-onset patients (<45 y) had the highest relative mortality risk (HR = 3.35), which was amplified by smoking (HR = 5.27) and inflammation (hsCRP≥3mg/L: HR = 10.15); midlife onset (45- 54 y) represented the optimal prevention window (NNT = 15), yet with extreme female vulnerability (Stage 4 HR=14.25 vs.

SUBMITTER: Dai J 

PROVIDER: S-EPMC12440721 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature