Polystyrene nanoplastics induce oxidative stress in <i>Aurelia coerulea</i> polyps, microglia, and mice.

ABSTRACT:

Introduction

This study investigates the oxidative stress responses induced by polystyrene nanoplastics (PS-NPs) across three distinct biological models-Aurelia coerulea polyps, BV2 microglial cells, and ICR (Institute of Cancer Research) mice. We aimed to explore the involvement of the mitogen-activated protein kinase (MAPK) signaling pathway as a potential mechanism in invertebrate and cellular systems, while evaluating neurobehavioral outcomes in vivo.

Methods

Oxidative stress markers including catalase (CAT), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) were quantified in all the three models. Transcriptomic analysis and RT-qPCR validation targeting the MAPK signaling pathway were performed in Aurelia coerulea polyps and BV2 microgli

SUBMITTER: Song M 

PROVIDER: S-EPMC12440749 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature