Zinc alleviates stroke development through autophagy-mediated modulation of immune microenvironment.

ABSTRACT:

Background

Stroke is a leading cause of death and long-term disability worldwide and is increasingly recognized as a neuroinflammatory, immune-mediated disease. Acute ischemia triggers robust activation and infiltration of innate immune cells, exacerbating neuronal injury. Zinc is an essential micronutrient with known immunomodulatory and autophagy-regulating roles, but its impact on stroke-driven neuroinflammation remains unclear. We aimed to investigate whether zinc protects against ischemic brain injury by modulating autophagy and the immune microenvironment.

Methods

Genome-wide association (GWAS) and NHANES cohort analyses were performed to assess the association between zinc intake levels and stroke risk. Pathway enrichment analysis, PPI network construction, and diagno

SUBMITTER: Qiu Z 

PROVIDER: S-EPMC12440758 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature