Evaluation of degree centrality and neurological outcomes in patients with herpes simplex encephalitis.

ABSTRACT:

Objective

This study aimed to investigate the association between changes in cerebral degree centrality (DC) and clinical outcomes in patients with herpes simplex encephalitis (HSE).

Methods

All participants underwent functional magnetic resonance imaging (fMRI), and DC analysis was used to identify voxels that showed changes in whole-brain functional connectivity with other voxels. DC was evaluated using the fMRI graph method, and comparisons between HSE patients and controls were performed. The National Institutes of Health Stroke Scale (NIHSS), the Glasgow Coma Scale (GCS), and the modified Rankin Scale (mRS) were assessed for all HSE patients.

Results

A total of 70 HSE patients and 76 controls were included in our data analysis. In the HSE group, DC values were in

SUBMITTER: Liu D 

PROVIDER: S-EPMC12440766 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature