Ictal phase-amplitude coupling as a biomarker for seizure onset zone in neocortical epilepsy.

ABSTRACT:

Objective

To assess ictal phase-amplitude coupling (PAC) dynamics during seizure generation and explore whether ictal PAC analysis can help identify the seizure onset zone (SOZ) in neocortical epilepsy.

Methods

We analyzed ictal intracranial electroencephalography recordings from 22 seizures in six patients with drug-resistant neocortical epilepsy who achieved International League Against Epilepsy Class I outcomes following resection surgery. PAC strength was quantified using the modulation index (MI), computed by coupling the amplitude of high-frequency bands (ripples: 80-200 Hz; fast ripples: 200-300 Hz) with the phase of slow-wave bands (1-2 Hz, 2-3 Hz, 3-4 Hz and 4-8 Hz). MI values were compared across SOZ, peri-SOZ (adjacent electrodes), and non-SOZ regions. Localizatio

SUBMITTER: Nishioka K 

PROVIDER: S-EPMC12440772 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature