Mortality and trends of pulmonary arterial hypertension, 1990-2021: a population-based study.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a progressive disease associated with high fatality rate. Comprehensive evidence concerning the epidemiology of PAH mortality is lacking. The present study aimed to assess the mortality and trends of PAH at global, regional, and national levels from 1990 to 2021.

Methods

The estimates and their 95% uncertainty interval for case number of PAH were collected from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2021. Age standardization by direct method was used to estimate the age-standardized mortality rate (ASMR) for PAH. We investigated the temporal trends of estimated ASMR from 1990 to 2021 and further predicted its changes in the next 15 years, decomposed the trends based on demographic factors and e

SUBMITTER: Jiang L 

PROVIDER: S-EPMC12440859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature