Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation.

ABSTRACT:

Introduction

Gabapentin (GBP) is widely prescribed to older patients for pain management. Recent clinical studies highlight that GBP adversely affect cognitive function in older patients. GBP binds to the α2δ1 subunit of L-type voltage-gated Ca²⁺ channels to inhibit Ca²⁺ channel current. It is being increasingly recognized that GBP affects neuronal activity in multifaceted ways. However, the molecular mechanism underlying GBP's impact on cognitive function in older subjects remains unelucidated.

Methods

Aged mice (18-month-old, female) were subjected to spared nerve injury (SNI) or sham surgery and treated with GBP for 60 days. Learning and memory were assessed using novel object recognition (NOR) test and contextual and cued fear conditioning test (FCT

SUBMITTER: Xia S 

PROVIDER: S-EPMC12440869 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature