<i>SPARC</i> aberrant methylation in idiopathic pulmonary fibrosis: an explorative study.

ABSTRACT:

Introduction

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease (ILD) characterized by progressive accumulation of extracellular matrix in the lung and dysregulated activation of specific signaling pathways. Recent advances in the understanding of the biological bases of IPF identified the silencing of secreted protein acidic and rich in cysteine (SPARC) as a key modulator in the pathogenesis of IPF, although the mechanisms underlying the SPARC aberrant modulation remain to be fully elucidated.

Methods

Here we investigated the aberrant methylation at the promoter gene region as a possible mechanism of SPARC deregulation in IPF. Formalin-fixed paraffin-embedded (FFPE) tissues from a cohort of 44 patients with IPF and from a control-group of 23 non-idio

SUBMITTER: Fabrizio FP 

PROVIDER: S-EPMC12440879 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature