γ-Oryzanol-Loaded PLGA nanoparticles: enhanced drug delivery and therapeutic efficacy for breast cancer therapy.

ABSTRACT:

Introduction

Breast cancer treatment is plagued by systemic toxicity and drug resistance, prompting the search for better drug delivery systems, with oryzanol, a natural compound with anti-tumor potential but poor water solubility, emerging as a candidate. PLGA nanoparticles, a biodegradable and FDA-approved platform, are designed to encapsulate oryzanol, addressing its solubility issues and enabling targeted, controlled release to enhance anti-breast cancer efficacy. This study focuses on developing and characterizing γ-oryzanol-loaded PLGA (γ-oryzanol@PLGA) nanoparticles, evaluating their formulation, cellular effects, and mechanisms, intending to lay a preclinical foundation for oryzanol as a safe adjuvant therapy for breast cancer.

Methods

To address this unmet need, thi

SUBMITTER: Ma T 

PROVIDER: S-EPMC12440946 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature