Identification of necroptosis-associated mRNA biomarkers in kidney clear cell carcinoma.

ABSTRACT:

Introduction

Kidney clear cell carcinoma (KIRC) is the most common subtype of renal malignancy with a high mortality rate. It is difficult to treat and often leads to death due to its genomic heterogeneity, metastatic nature, and limited effectiveness of targeted and immunotherapies. Recent studies showed that the progression of KIRC is frequently accompanied by significant changes in necroptosis while these studies were limited by small gene sets, which increases the risk of missing low-expressed yet important genes.

Methods

This study focused on necroptosis-associated genes within the context of KIRC and performed a complete closed-loop studies by gene screening, gene expression analysis, model validation and experimental translation.

Results

Among screened nine cor

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12440986 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature