Involvement of resistant bacteria in the severity of refractory osteonecrosis of the jaw.

ABSTRACT:

Purpose

Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are relatively rare and refractory, and there is no consensus regarding the bacteria associated with their development. This study was conducted to identify the bacteria associated with refractory ORN and MRONJ, including severe cases.

Methods

Patients who underwent surgery for osteonecrosis of the jaw were included in this study. Bacterial culture specimens were obtained from tissue as deeply as possible. Severe cases of ORN and MRONJ were defined as stage IV of Lyon's classification and stage III of the AAOMS classification, respectively. Demographic data, clinical features, antimicrobials usage, and bacteria detected were analysed to determine the factors associated with severe diseas

SUBMITTER: Kusumoto J 

PROVIDER: S-EPMC12441049 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature