Saturation effect of brachial-ankle pulse wave velocity on first stroke in adults with hypertension: a prospective cohort study.

ABSTRACT:

Background

Previous studies have reported a linear association between brachial-ankle pulse wave velocity (baPWV) and stroke in hypertensive individuals, primarily in foreign countries, with few studies conducted in China. This study aimed to investigate the saturation effect of baPWV on the first stroke in adults with hypertension and propose a possible inflection point of baPWV at which the saturation effect occurs.

Methods

A total of 7,198 adults with hypertension and baseline baPWV were enrolled from the China Hypertension Registry Study. The outcome of this study was the first stroke. Cox proportional hazards regression, smoothing curve fitting (restricted cubic spline), Kaplan-Meier survival curve analysis, and subgroup analysis were used to investigate the association

SUBMITTER: Zhou W 

PROVIDER: S-EPMC12441068 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature