Rational designing and synthesizing an antimicrobial peptide from bovine milk casein and evaluating its biological properties.

ABSTRACT: The overuse of antibiotics has led to a growing crisis-antimicrobial resistance, making it harder to treat infections and pushing scientists to find new solutions. Among the most promising alternatives are bioactive peptides, especially antimicrobial peptides, which offer broad-spectrum activity with a lower risk of resistance. One exciting source of these peptides is milk, particularly casein-derived peptides, which naturally possess antimicrobial properties. This study focused on bovine milk casein to design and synthesize a novel antimicrobial peptide. We evaluated several properties, such as antimicrobial activity, cytotoxicity, stability, and structure, using computational predictions to select the most promising candidate. The peptide NCP1 emerged as the best option and was synthesiz

SUBMITTER: Pourhosseini SR 

PROVIDER: S-EPMC12441096 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature