Efficacy of platelet-rich plasma injection with percutaneous endoscopic lumbar discectomy for lumbar disc herniation: a systematic review and meta-analysis.

ABSTRACT:

Objective

Our aim was to compare the efficacy of percutaneous endoscopic lumbar discectomy (PELD) with or without platelet-rich plasma (PRP) injections for the treatment of lumbar disc herniation (LDH).

Methods

Literature was searched in six databases from inception to 2 May 2025. Meta-analysis was performed using stata17 software.

Results

Eight studies were included, comprising a total of 717 patients (349 in the treatment group and 368 in the control group). At the final follow-up, the treatment group significantly provided lower visual analogue scale, intervertebral disc protrusion, recurrence rates, Oswestry disability index and higher intervertebral disc height, Japanese Orthopaedic Association scores, spinal canal cross-sectional area and ratio value of disc gre

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12441161 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature