A bioreactor-based platform for investigating the early response of human periodontal ligament stem cells to intermittent mechanical stretching.

ABSTRACT: During development and daily activities, biological tissues are frequently exposed to mechanical stimuli, which are crucial for tissue maintenance and regeneration. The periodontal ligament (PDL), which connects the tooth root to the alveolar bone of the jaw, is among the tissues most exposed to mechanical loading and has recently received increasing attention due to the rising prevalence of periodontitis, a chronic inflammatory disease that leads to the progressive destruction of tooth-supporting structures. Understanding the mechanobiology of PDL could be essential for guiding effective regenerative strategies. To address this, a bioreactor-based platform for applying controlled stretch stimulation to adherent cells was developed, and the early biological response of human primary PDL st

SUBMITTER: Putame G 

PROVIDER: S-EPMC12441168 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature