Deciphering peripheral nerve myelination by using Schwann cell expression profiling.

ABSTRACT: Although mutations in multiple genes are associated with inherited demyelinating neuropathies, the molecular components and pathways crucial for myelination remain largely unknown. To approach this question, we performed genome-wide expression analysis in several paradigms where the status of peripheral nerve myelination is dynamically changing. Anchor gene correlation analysis, a form of microarray analysis that integrates functional information, using correlation-based clustering, with a statistically rigorous test, the Westfall and Young step-down algorithm, was applied to this data set. Biological pathways active in myelination, genes encoding proteins involved in myelin synthesis, and genes whose mutation results in myelination defects were identified. Many known genes and previously

SUBMITTER: Nagarajan R 

PROVIDER: S-EPMC124412 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature