Insulin resistance as potential mediator linking ApoB/ApoA1 to MAFLD, but not inflammation.

ABSTRACT:

Aims

Metabolic-associated fatty liver disease (MAFLD) is closely associated with insulin resistance (IR) and systemic inflammation. Apolipoprotein A1 (ApoA1) and Apolipoprotein B (ApoB), as notable non-traditional lipid markers, have demonstrated distinct advantages in identifying risks related to metabolic syndrome and coronary atherosclerosis, yet its association with MAFLD and the mediating roles of IR/inflammation remain unclear.

Methods

This retrospective investigation involved 1061 participants, categorized into a non-MAFLD group (n = 529) and an MAFLD group (n = 532). Univariate and multivariate logistic regression models, Spearman's correlation, and mediation analysis were utilized to explore the intricate associations between ApoB/ApoA1, MAFLD, inflamm

SUBMITTER: Yang M 

PROVIDER: S-EPMC12441268 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature