Association between pretreatment emotional distress and survival outcomes in patients with advanced non-small-cell lung cancer: an individual patient data meta-analysis of 4632 patients in seven trials.

ABSTRACT:

Background

Emotional distress (ED) is associated with worse survival outcomes in patients with melanoma and non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). However, several preclinical studies suggest the association between stress and cancer treatment extends beyond ICIs alone.

Objectives

To systematically evaluate the relationship between ED and NSCLC patient prognosis.

Design

This study is an individual patient data (IPD) meta-analysis.

Data sources and methods

Relevant studies were identified from the PubMed, Web of Science, The Cochrane Library, Embase, and Vivli databases to obtain IPD up to February 2025. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the association between ED

SUBMITTER: Li X 

PROVIDER: S-EPMC12441296 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature