Maternal Folic Acid Supplementation and Childhood Metabolic Health: Analyzing Direct and Indirect Effects.

ABSTRACT: This study examines the direct and indirect effects of maternal folic acid (FA) supplementation on childhood metabolic outcomes, including blood pressure (BP), insulin resistance (HOMA-IR), and insulin sensitivity (QUICKI), with body mass index (BMI), waist circumference (WC), and skinfold thickness as mediators. This cross-sectional study analyzed data from 2577 children (9-13 years) from the Healthy Growth Study (2007-2009, Greece). Maternal FA intake was reported via parental questionnaires. BMI, WC, and skinfold thickness were measured using standardized protocols. BP, fasting glucose, and insulin were assessed to compute HOMA-IR and QUICKI. Structural equation modeling evaluated direct and indirect effects, adjusting for maternal, pregnancy, and child-related confounders. FA supplemen

SUBMITTER: Batra M 

PROVIDER: S-EPMC12441301 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature