Inhibition of Iron Death by <i>Lycium barbarum</i> Polysaccharides Ameliorates Myocardial Injury in Sepsis: A Pharmacological Mechanism Study Based on the NRF2/HO-1 Pathway.

ABSTRACT: Sepsis remains a leading global cause of mortality, with sepsis-induced myocardial injury (SIMI) being a critical determinant of clinical outcomes. Lycium barbarum L. (goji berry), a traditional Chinese herb, has demonstrated therapeutic potential in sepsis-related organ injuries through multiple pathways. However, its role and mechanisms in SIMI remain unexplored. A network pharmacology approach identified candidate targets of Lycium barbarum via TCMSP and SwissTargetPrediction, intersected with sepsis/myocardial injury-related targets from GeneCards. Protein-protein interaction (PPI) networks were constructed using STRING and analyzed via Cytoscape's cytoHubba plugin. Enriched pathways were explored through KEGG/GO analyses. Transcription factor prediction, molecular dockin

SUBMITTER: Niu Z 

PROVIDER: S-EPMC12441308 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature