IgG4-Related Aortitis as a Driver of Coronary Artery Stenosis and Ischemic Cardiomyopathy.

ABSTRACT:

Background

Vasculitis and aortitis can contribute to early coronary artery stenosis, causing ischemic cardiomyopathy.

Case summary

A 45-year-old woman with recently diagnosed heart failure and no known cardiac risk factors was found to have multivessel coronary artery disease on elective angiography, prompting coronary bypass surgery, during which her aorta appeared severely inflamed with circumferential thickening, although the stenosed coronaries had no signs of atherosclerosis, and histologic examination indicated aortitis secondary to IgG4-related disease as the driver of her ischemic cardiomyopathy.

Discussion

IgG4-related disease manifests in a variety of organs and tissues and is a well-known cause of aortitis with potential coronary involvement, often requirin

SUBMITTER: Olivieri N 

PROVIDER: S-EPMC12441341 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature