Nonbacterial Thrombotic Endocarditis as a Presenting Paraneoplastic Manifestation of Acute Promyelocytic Leukemia.

ABSTRACT:

Background

Nonbacterial thrombotic endocarditis (NBTE) is a noninflammatory endocarditis that occurs in hypercoagulable states. Acute promyelocytic leukemia (APL) is an aggressive form of acute leukemia associated with significant coagulopathy.

Case summary

A 45-year-old woman with new pulmonary emboli and progressive heart failure developed pancytopenia, leading to diagnosis of APL and cardiogenic shock secondary to NBTE of the mitral valve. APL was treated with induction chemotherapy, alongside inotropic support for cardiogenic shock. After cancer remission, she underwent mitral valve replacement, resolving the cardiogenic shock.

Discussion

NBTE is a recognized complication of solid malignancy but is rarely associated with leukemia. Fewer than 5 cases have been repo

SUBMITTER: Fradin JJ 

PROVIDER: S-EPMC12441457 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature