Isolated Nonischemic Left Bundle Branch Block Resulting in Heart Failure in Hodgkin Lymphoma Survivors Post-Radiation.

ABSTRACT:

Background

Relatively little is known about the clinical features of left bundle branch block (LBBB) in patients previously treated with chest radiation therapy (RT).

Case summary

Six long-term Hodgkin lymphoma survivors developed isolated, nonischemic LBBB decades after chest RT. None had prior conduction issues or coronary artery disease on evaluation. We describe in detail 3 patients with new focal LBBB who developed worsening low/normal left ventricular (LV) systolic function and heart failure onset, which improved with cardiac resynchronization therapy.

Discussion

Dense calcification of the subaortic/LV outflow tract region was observed on echocardiography, an area included in the RT field overlap for Hodgkin lymphoma and through which the left bundle branch cour

SUBMITTER: Mangano CM 

PROVIDER: S-EPMC12441546 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature