Plasma placental growth factor as a biomarker for subcortical ischemic vascular dementia and its cognitive correlation mediated by white matter hyperintensities.

ABSTRACT:

Introduction

Placental growth factor (PlGF) was recently shown to be associated with cerebrovascular and neurodegenerative diseases. The changes of PlGF level in patients with subcortical ischemic vascular dementia (SIVD) and its associations with cognitive function remain unclear.

Methods

Seventy patients with SIVD, 102 patients with symptomatic Alzheimer's disease, 40 patients with frontotemporal lobar degeneration, and 38 cognitively unimpaired controls (CUCs) were included. The plasma level of PlGF was measured via electrochemiluminescence immunoassay.

Results

The plasma PlGF level was significantly elevated in patients with SIVD compared with CUCs, and showed a high accuracy with an area under the curve of 0.893. Mediation analysis revealed that white matter hype

SUBMITTER: Che P 

PROVIDER: S-EPMC12441591 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature